Markdown version of Reverse Engineering the source code of the BioNTech/Pfizer SARS-CoV-2 Vaccine

The big BNT162b2 archive

All vaccine data here is sourced from this World Health Organization document.

This describes the RNA contents of the BNT162b2 SARS-CoV-2 vaccine. We should all be very grateful that BioNTech has shared this data with us. And of course we should also be grateful to the many many researchers that worked for decades to bring the state of the art to the point that such a vaccine could be developed. It is marvelous.

This GitHub repository is a companion to Reverse Engineering the source code of the BioNTech/Pfizer SARS-CoV-2 Vaccine and part 2.

In part 2 we find the challenge: Can we find an algorithm that turns the viral RNA into the vaccine RNA?

If so that would help explain how the vaccine is designed. It would also be useful for other researchers to turn viral RNA into RNA that gets converted into proteins efficiently.

Details are in part 2.

Data files

Owner
null
https://github.com/berthubert/bnt162b2
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Comments
  • Incorrect vaccine-s.fasta data (duplicate of ncov-s.fasta)

    Incorrect vaccine-s.fasta data (duplicate of ncov-s.fasta)

    ncov-s.fasta and vaccine-s.fasta contain the same sequence which appears to be the virus sequence (if I compare with side-by-side.csv). For example, the first two codons for the vaccine according to side-by-side.csv is ATG-TTC, however if you look at the first two codons in vaccine-s.fasta the first two codons are ATG-TTT.

  • WHO document link dead

    WHO document link dead

    Looks like a bit of link rot.

    The link in the readme: https://mednet-communities.net/inn/db/media/docs/11889.doc

    ...appears dead. Is there another copy?

  • Added the necessary 2nd stop codon for the vaccine

    Added the necessary 2nd stop codon for the vaccine

    In https://github.com/berthubert/bnt162b2/blob/master/side-by-side.csv at line 1275 there is only one TGA/UGA for the vaccine, but in https://berthub.eu/articles/posts/reverse-engineering-source-code-of-the-biontech-pfizer-vaccine/ at section "The end of the protein, next steps" you wrote that the vaccine uses 2 stop of these stop codons.

    Therefore I fixed it by adding the second stop codon at the end of the csv file.

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